Diluent high shear colloid mill

Colloidal mills for slow-release and controlled-release formulations, as well as auxiliary colloid mills for slow-release and controlled-release formulations,Colloidal mill for slow-release coating materials. Insoluble material colloid mill, enteric material colloid mill,CAP colloid mill, acrylic resin colloid mill, hydroxypropyl methylcellulose phthalate colloid mill, hydroxypropyl methylcellulose acetate succinate (HPMCAS) colloid mill areThe motor drives the rotating teeth (also known as the rotor) to rotate at high speed relative to the matching fixed teeth (also known as the stator) through a belt drive. The processed material is pressurized by its own weight or external pressure (which can be generated by a pump) to produce a downward spiral impact force. Through the adjustable gap between the fixed and rotating teeth, it is subjected to strong physical effects such as shear force, friction force, and high-frequency vibration, effectively emulsifying, dispersing, and crushing the material, achieving the effect of ultrafine crushing and emulsification of the material.

Slow controlled and delayed release preparations

Controlled release preparation: refers to a preparation in which a drug can be automatically released at a predetermined speed within a predetermined time, maintaining a constant blood drug concentration within an effective concentration range for a long time. Broadly speaking, controlled-release formulations include drugs that control their speed, direction, and duration, as well as targeted and transdermal absorption formulations.

Excipients for sustained-release and controlled release formulations:Most of them are polymer compounds, mainly including blockers, skeleton materials, and thickeners.

① Slow release coating material. Insoluble materials, enteric materials: CAP、 Acrylic resin L, S-type, hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPMCAS).

② Skeleton materials: bio soluble skeleton materials (fat, wax), hydrophilic colloidal skeleton materials (MC, CMC Na, HPMC, PVP, Carbopol, alginates, deacetylated chitosan), non soluble skeleton materials (EC, polymethacrylate, non-toxic polyvinyl chloride, polyethylene, ethylene vinyl acetate copolymer, silicone rubber).

③ Thickener: prolongs the efficacy of liquid medicine. Gelatin PVP、CMC、PVA、 Dextrose. The method of achieving slow and controlled release using diffusion principle:

① Coating: small pills or tablets coated, uncoated, or coated with different thicknesses of clothing.

Enteric coated material: utilizing its solubility properties to produce a sustained release effect. Such as Eudragit L and S, L is insoluble in strong acids but soluble in neutral solutions containing salts, S is difficult to dissolve in acidic and neutral media, and soluble in alkaline media. By combining L and S in appropriate proportions, a coating material that is soluble in a certain pH medium can be obtained. When mixed with plasticizers and coated using appropriate methods, a nearly zero grade controlled-release formulation can be produced.

Blockers: hydrophobic polymer substances, paraffin wax, * * * fatty acids, alcohols, monoglycerides of stearic acid, stearic acid, magnesium, calcium salts, cordyceps.

② Make microcapsules: The microcapsule membrane is a semi permeable membrane, forming a saturated solution for diffusion. The determining factors of drug release rate include the thickness of the capsule, the pore size of the micropores, and the curvature of the micropores.

③ Making insoluble skeleton sheets: using insoluble plastics such as non-toxic polyvinyl chloride, polyethylene, polyethylene acetate, poly (methyl methacrylate), and silicone rubber as the skeleton, suitable for water-soluble drugs. The determining factors of drug release rate include drug solubility, skeleton porosity, pore size, and pore curvature.

Preparation method: Mixing drugs with plastics; Wet granulation; Solvent based granulation and compression.

④ Increase viscosity to reduce diffusion rate: mainly used in injectable and other liquid formulations. Gelatin is used for heparin, CMC (1%) is used for procaine hydrochloride injection (3%).

⑤ Make plant emulsion: Melt insoluble drugs and pour them into the model to form, usually without adding excipients.

⑥ Made into medicinal resin: cation exchange resin is exchanged with organic amines, anion exchange resin is exchanged with organic carboxylates or sulfonates to form medicinal resin. Make capsules or tablets. Only dissociative drugs are suitable for making pharmaceutical resins. Due to limited exchange capacity, high-dose drugs are difficult to produce into drug resins.

⑦ Make emulsions: Water soluble drugs can be made into W/O emulsions. Water phase → oil phase → body fluid.

SID pipeline high shearColloid millCompared to horizontalColloid millComparison:

Rotational speed and shear force:

Colloid mill, the speed of the 3000/4700 RPM direct coupled motor determines the rotor speed

Linear velocity: V=3.14X0.55X3000/60=9 M/SV=3.14X0.55X4700/60=14M/S

Force: F=9/0.3X1000-=30000 S-1F=14/0.3X1000=42000 S-1

SID high shear colloid mill, accelerated by belt at 9000/14000RPM

Linear velocity: V= 3.14X0.055X90000/60=26 M/SV=3.14X0.055X14000/60=44 M/S

Force: F=23/0.2X1000=115000S-1F=40/0.2/X1000=200000S-1

This is an important factor in grinding and crushing, which is equivalent to 4-5 times that of the former

Equipment design and construction:

XX colloid mill, with a direct connection structure in the bedroom, has a long operating time and is prone to axis eccentricity, resulting in abnormal operation. It requires * personnel to dismantle the internal structure for replacement. And it is necessary to replace the damaged emulsifying head and shaft

SID high shear colloid mill, with a vertical split structure, has a long operating time, is not prone to shaft eccentricity, is easy to replace, and can be operated by ordinary personnel as long as the corresponding belt is replaced.

seal up:

Sid colloid mill, packing seal or skeleton seal, single mechanical seal or shaft seal, high leakage failure rate, product leakage into the motor, causing motor burnout

SID colloid mill, dual mechanical seals, easy to clean, reduces leakage * * *, can operate 24 hours without stopping, special German PDFE shaft seal, can run for 10000 hours, can choose high-quality German mechanical seal. In general, our mechanical seal can withstand a pressure of 16 bar. According to the pressure of the mechanical seal, it is generally 2-3 bar higher than the pressure of the sealing chamber, which determines that our inlet pressure can reach 12-13 bar

Product effect:

The Hyde colloid mill has limited particle size and fineness, making it difficult to achieve particle sizes below 10 microns. The repeatability is poor, and the product particle size distribution is uneven

The Hyde high shear colloid mill can achieve particle processing of 0.1-1 microns, with uniform particle size distribution and nanoscale dispersion, emulsification, and crushing

The liquid after E. coli cell lysis contains 40-70% protein, 10-30% nucleic acid, 2-10% polysaccharides, and 10-15% lipids. The reason why this liquid appears viscous is due to the release of nucleic acids after cell breakage. DNase can be added to digest nucleic acid contamination.

The Sid pipeline high shear grinding and dispersing machine is a high-precision equipment developed by SID R&D engineers in 2013 for fine grinding, dispersion, emulsification, and homogenization of materials. The high shear grinding and dispersing machine combines the high-speed grinding, dispersion, emulsification, and homogenization functions of SID high shear colloid mill and SID high shear dispersion homogenization emulsifying machine. The equipment speed can reach 18000 rpm, which is 4-5 times the current XX equipment speed

XMD2000 imported ultra-high shear grinding and dispersing machine
Grinding and dispersing machine is a high-tech product composed of colloid grinding and dispersing machines.

The first level consists of three-level sawtooth protrusions and grooves with increasing precision. The stator can be infinitely adjusted to the desired distance between the rotors. Under enhanced fluid turbulence. The groove can change direction at each level.
The second stage is composed of a stator. The design of the dispersing head also effectively meets the needs of substances with different viscosities and particle sizes. The difference in the design of the stator and rotor (emulsifying head) between online and batch machines is mainly due to the requirements for conveying performance. It is particularly important to note that the difference between coarse precision, medium precision, fine precision, and other types of working heads is not only the arrangement of specified rotor teeth, but also an important difference in the geometric characteristics of different working heads. The width of the slot and other geometric features can alter the different functions of the stator and rotor working heads.

The following is a model table for reference:

Diluent high shear colloid mill